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ARANZ Medical Clinical Research Services (PDF)
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Silhouette for Clinical Trials – US Letter (PDF)
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Evidence-based wound surveillance – US Letter (PDF)
Evidence-based wound surveillance – A4 (PDF)

Published Research

The following list of published articles demonstrates the range and breadth of studies that Silhouette is used in.

2025 – Korzendorfer, H. et al. Wounds. An Overview and Survey of US Food and Drug Administration–Registered Wound Imaging Devices Capable of Determining Percentage Area Reduction and/or Percentage Volume Reduction. (online)
2025 – Kelso, M.R. et al. Journal of Wound Care. Use of near infrared spectroscopy in post-acute care: analysis of real-world clinical decision-making. (online)
2025 – Edwick, D.O. et al. European Burn Journal. Enhancing Burn Recovery: A Systematic Review on the Benefits of Electrical Stimulation in Accelerating Healing. (online)
2025 – Lan, Nick S.R. et al. The Physiological Society – Wiley. The combined impact of chronic kidney disease and ulcer severity on incident cardiovascular events in patients with diabetes-related foot ulceration. (online)
2025 – Nuutila, K. et al. International Wound Journal – Wiley. A Prospective, Controlled, Randomised, Clinical Study of Negative Pressure Device Without Foam or Gauze for Skin and Soft Tissue Defects. (online)
2025 – Shawa H. et al. American Diabetes Association. Cellular Versus Acellular Matrix Products for Diabetic Foot Ulcer Treatment: The Dermagraft and Oasis Longitudinal Comparative Efficacy Study (DOLCE)—A Randomized Clinical Trial. (online – restricted access)
2025 – Slade, H.B. et al. Mary Ann Liebert Advances in Wound Care. Effects of a New Enzymatic Debrider (SN514-066b) on Eschar Protein Digestion, Burn Wound Debridement, and Healthy Skin Irritation. (online)
2025 – Lan, N. S.R. et al. Springer. Increased risk of major adverse cardiovascular events in patients with deep and infected diabetes-related foot ulcers. (online)
2025 – Ramsey, Jason A. et al. Journal of Neurosurgery. Comprehensive craniometry for sagittal synostosis. (online)
2025 – Neelon, J. et al. Science Direct. Development of an experimental heterogeneous burn wound model. (online – restricted access)
2025 – Pai, Chi-Yun, et al. Journal of Wound Care. Automated pressure ulcer dimension measurements using a depth camera. (online – restricted access)
2025 – Wang, Yushu, et al. Wiley Advanced. On‐Demand Silk Protein‐Based Spray for Acute Burn Wound Management – Wang – Advanced Functional Materials. (online – restricted access)
2024 – Napit, Indra B. et al. PLOS Neglected Tropical Diseases. A randomised Trial of Autologous Blood products, leukocyte and platelet-rich fibrin (L-PRF), to promote ulcer healing in LEprosy: The TABLE trial (online)
2024 – Fulchand, S. et al. Research Square. Natural History Study of Recessive Dystrophic Epidermolysis Bullosa Wounds and Patient Reported Outcomes Using Mobile Application Home Photography. (online)
2024 – Stone, R. et al. Biomedicines journal by MDPI. Comparison of Intact Fish Skin Graft and Allograft as Temporary Coverage for Full-Thickness Burns: A Non-Inferiority Study. (online)
2024 – Ting, M. et al. Journal of Foot and Ankle Research – Wiley. A mouldable fibreglass backslab device as a novel approach to offload chronic plantar foot ulcers: A retrospective observational audit. (online)
2024 – Fairlamb, David M. et al. International Wound Journal – Wiley. First clinical evaluation of the safety and efficacy of tarumase for the debridement of venous leg ulcers. (online)
2024 – Fleming D. et al. National Library of Medicine – PubMed Central. HOCl-producing Electrochemical Bandage is Active in Murine Polymicrobial Wound Infection. (online)
2024 – Samdavid Thanapaul, R.J. et al. Journal of Fungi – MDPI. Development of a Combat-Relevant Murine Model of Wound Mucormycosis: A Platform for the Pre-Clinical Investigation of Novel Therapeutics for Wound-Invasive Fungal. (online)
2024 – Lan, N.S.R. et al. Diabetologia – Springer. Increased risk of major adverse cardiovascular events in patients with deep and infected diabetes-related foot ulcers. (online)
2024 – Tamarat, R. et al. International Journal of Radiation Biology. Radiation-induced gastrointestinal and cutaneous injuries: understanding models, pathologies, assessments, and clinically accepted practices. (online)
2024 – Bechara, N. et al. Scientific Reports – Nature. The association between tobacco smoking and systolic toe pressures in active foot ulceration. (online)
2024 – Bechara N. et al. Advances in Wound Care. Prospective Evaluation of Vitamin C, Vitamin D, and Zinc Deficiencies in Patients with Active Foot Ulceration. (online)
2024 – Gysens, L. et al. Veterinary Dermatology – Wiley. Longitudinal pilot study examining the effect of punch biopsy on equine sarcoid growth dynamics. (online – restricted access)
2024 – Neelon, J. et al. Burns – ScienceDirect. Development of an experimental heterogeneous burn wound model. (online – restricted access)
2024 – Christy, S. et al. Journal of Surgical Research – ScienceDirect. Topical Noneuphoric Phytocannabinoid Elixir 14 Reduces Inflammation and Mitigates Burn Progression. (online – restricted access)
2024 – Neelon, J. et al. Burns – ScienceDirect. Topical application of anti-inflammatory agents on burn wounds and their effect on healing. (online – restricted access)
2024 – Zhao, R. et al. Wound Repair and Regeneration – Wiley. A recombinant signalling-selective activated protein C that lacks anticoagulant activity is efficacious and safe in cutaneous wound preclinical models. (online – restricted access)
2024 – Mishra, RK. et al. Journal of Diabetes Science and Technology – Sage Journals. The Application of Digital Frailty Screening to Triage Nonhealing and Complex Wounds. (online – restricted access)
2024 – Nuutila, K. at al. Advances in Wound Care. Split-Thickness Skin and Dermal Pixel Grafts Can Be Expanded up to 500 Times to Re-Epithelialize a Full-Thickness Burn Wound. (online – restricted access)
2024 – Niese, B.A. et al. University of Texas Libraries. Quantitative image analysis elucidates properties of complex biological systems. (online – restricted access)
2024 – Thompson, M.A. et al. Military Medicine – Oxford Academic. Subcutaneous Anti-inflammatory Therapies to Prevent Burn Progression in a Swine Model of Contact Burn Injury. (online – restricted access)
2024 – Tan, G. et al. Journal of Diabetes Science and Technology. Reliability of a Three-Dimensional Wound Camera for Measurement of Diabetes-Related Foot Ulcers in a Clinical Setting. (online)
2024 – Agbavor, B. et al. Journal of Clinical Tuberculosis and other Mycobacterial Diseases. Clinical and microbiological predictors of healing in Buruli ulcer disease. (online)
2024 – Baker, C. et al. American Society for Microbiology. L-arginine supplementation abrogates hypoxia-induced virulence of Staphylococcus aureus in a murine diabetic pressure wound model. (online)
2023 – Janowska, A. et al. The International Journal of Lower Extremity Wounds. Fractional Epidermal Skin Grafts in Hard-to-Heal Wounds: Case Series. (online)
2023 – Keenan, C. et al. Wound Repair and Regeneration. Full-thickness skin columns: A method to reduce healing time and donor site morbidity in deep partial-thickness burns. (online)
2023 – Larson, D. et al. Military Medicine. Evaluation of Topical Off-the-Shelf Therapies to Reduce the Need to Evacuate Battlefield-Injured Warfighters. (online)
2023 – Janowska, A. et al. Journal of Wound Management. Fractional Epidermal Skin Grafts in Hard to Heal Wounds. (online)
2023 – Alahakoon, C. Thesis, James Cook University. Burden of Diabetes-Related Foot Disease in North Queensland, Australia. (online)
2023 – Valdera, F. et al. Journal of Surgical Research. Topical Synthetic Platelets Loaded with Gentamicin Decrease Bacteria in Deep Partial-Thickness Burns. (online)
2023 – Chan, R. et al. Advances in Wound Care. A Prospective, Randomized, Controlled Study to Evaluate the Effectiveness of a Fabric-Based Wireless Electroceutical Dressing Compared to Standard-of-Care Treatment Against Acute Trauma and Burn Wound Biofilm Infection. (online)
2023 – Abu Rached, N. et al. Journal of Clinical Medicine. Cold Plasma Therapy in Chronic Wounds—A Multicenter, Randomized Controlled Clinical Trial (Plasma on Chronic Wounds for Epidermal Regeneration Study): Preliminary Results. (online)
2023 – Bull RH, Clements D, Collarte AJ, Harding KG. International Wound Journal. The impact of a new intervention for venous leg ulcers: A within-patient controlled trial. (online)
2022 – Ruamsap, N. et al. Military Medicine. Chronic Wound Infection Model of Acinetobacter baumannii in Outbred Mice. (online)
2021 – Kemp Bohan, P. et al. International Wound Journal. Impact of dermal matrix thickness on split-thickness skin graft survival and wound contraction in a single-stage procedure. (online)
2021 – Alahakoon, C. et al. Journal of Diabetes Science and Technology. Repeatability, Completion Time, and Predictive Ability of Four Diabetes-Related Foot Ulcer Classification Systems. (online)
2021 – Mahlapuu, M. et al. Wound Repair and Regeneration. Evaluation of LL-37 in healing of hard-to-heal venous leg ulcers: A multicentric prospective randomised placebo-controlled clinical trial (online)
2021 – Bull, R.H. et al. International Wound Journal – Wiley. Measuring progress to healing: A challenge and an opportunity.
2021 – Engeman, E. et al. Pharmaceuticals. Synergistic Killing and Re-Sensitization of Pseudomonas aeruginosa to Antibiotics by Phage-Antibiotic Combination Treatment (online)
2021 – Yaw Ampem Amoako, et.al. BMC Infectious Diseases. Co-infection of HIV in patients with Buruli ulcer disease in Central Ghana (online)
2020 – Jockenhöfer, F. et al. Journal of the German Society of Dermatology. Influence of placebo effects on quality of life and wound healing in patients with chronic venous leg ulcers (online)
2020 – Mamone, V. et al. IEEE Journal of Translational Engineering in Health and Medicine. Monitoring Wound Healing With Contactless Measurements and Augmented Reality (online)
2020 – Moelleken, M. et al. Journal of the German Society of Dermatology. Pilot study on the influence of cold atmospheric plasma on the bacteriological contamination and healing tendency of chronic wounds. (In press)
2020 – Rouse, M. et al. Frontiers in Microbiology. Impact of Frequent Administration of Bacteriophage on Therapeutic Efficacy in an A. baumannii Mouse Wound Infection Model (online)
2019 – Bianchi, C. et. al. International Wound Journal – Wiley. Variations in study outcomes relative to intention-to-treat and per-protocol data analysis techniques in the evaluation of efficacy for treatment of venous leg ulcers with dehydrated human amnion/chorion membrane allograft (PDF)
2019 – Bourke, A; Scott, N. Journal of Wound Management and Prevention. Top-Scoring Nurse Research Abstracts Symposium on Advanced Wound Care (SAWC) Spring 2019(online)
2019 – Cazzell, S. Wounds. A Randomized Controlled Trial Comparing a Human Acellular Dermal Matrix Versus Conventional Care for the Treatment of Venous Leg Ulcers (online)
2019 – Frimpong, M. et al. PLOS Neglected Tropical Disease. Paradoxical reactions in Buruli ulcer after initiation of antibiotic therapy: Relationship to bacterial load (online)
2019 – Kern, J.S. et al. Trials. Oleogel-S10 Phase 3 study “EASE” for epidermolysis bullosa: study design and rationale (online)
2019 – Kirsner, R. et al. Wound Repair and Regeneration. A prospective, randomized, controlled clinical trial on the efficacy of a single‐use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of chronic ulcers of the lower extremities (online)
2019 – Tettelbach, W. et al. International Wound Journal. A multicentre prospective randomised controlled comparative parallel study of dehydrated human umbilical cord (EpiCord) allograft for the treatment of diabetic foot ulcers (online)
2019 – Zurawski, D. et al. Advanced Woundcare (New Rochelle). A Porcine Wound Model of Acinetobacter baumannii Infection (online)
2018 – Chiang, N. et al. Advanced Skin Woundcare. Clinical Evaluation of Portable Wound Volumetric Measurement Devices (online) PDF Link
2018 – Motley, T. et al. Advanced Woundcare (New Rochelle). Clinical Outcomes for Diabetic Foot Ulcers Treated with Clostridial Collagenase Ointment or with a Product Containing Silver (online)
2018 – Patil, P. et al. PLoS One. Fluorinated methacrylamide chitosan hydrogel dressings enhance healing in an acute porcine wound model (online)
2018 – Romanelli, M. et al. Eplasty. Skin Grafting in Pyoderma Gangrenosum (online)
2018 – Romanelli, M et al. Journal of Woundcare. Evaluation of fluorescence biomodulation in the real-life management of chronic wounds: the EUREKA trial (online)
2018 – Serena, T et al. WOUNDS. Validation of a Clinically Relevant Diagnostic Marker for Early Diagnosis of Infection in Chronic Wounds (online)
2017 – Bianchi, C. A. et. al. International Wound Journal. A multicentre randomised controlled trial evaluating the efﬁcacy of dehydrated human amnion/chorion membrane (EpiFix®) allograft for the treatment of venous leg ulcers (PDF)
2017 – Cazzell, S et al. The International Journal of Tissue Repair and Regeneration. A randomized clinical trial of a human acellular dermal matrix demonstrated superior healing rates for chronic diabetic foot ulcers over conventional care and an active acellular dermal matrix comparator (online)
2017 – Foubert, P. et al. Autologous adipose-derived regenerative cell therapy modulates development of hypertrophic scarring in a red Duroc porcine model (online)
2017 – Najafi, B et al. Journal of Diabetes Science and Technology. Can’t Stand the Pressure: The Association Between Unprotected Standing, Walking, and Wound Healing in People With Diabetes (online)
2017 – Romanelli, M. et al. Drug Design, Development and Therapy. EUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis (PDF)
2017 – Sarpong-Duah, M. et al. PLOS Journal of Neglected Tropical Diseases. Clearance of viable Mycobacterium ulcerans from Buruli ulcer lesions during antibiotic treatment as determined by combined 16S rRNA reverse transcriptase /IS 2404 qPCR assay (online)
2017 – Vitse, J. et al. The International Journal of Lower Extremity Wounds. A Double-Blind, Placebo-Controlled Randomized Evaluation of the Effect of Low-Level Laser Therapy on Venous Leg Ulcers (online)
2016 – Constantine, R.S. et al. International Wound Journal. Validation of a laser-assisted wound measurement device in a wound healing model (online)
2016 – Dini, V. et al. Wound Healing Research Unit Department of Dermatology, University of Pisa, Italy. Preliminary evaluation of biophotonic therapy in chronic wounds (PDF)
2016 – Foubert, P. et al. International Journal of Radiation Biology. Development of a combined radiation and full thickness burn injury minipig model to study the effects of uncultured adipose-derived regenerative cell therapy in wound healing (PDF)
2016 – Foubert, P. et al. Advances in Wound Care (New Rochelle). Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods (online)
2016 – Nikolis, A. et al. Diabetic Foot Canada, vol 4, no.2 Evaluation of BioPhotonic Therapy in a non-healing diabetic foot ulcer: A case report (PDF)
2016 – Nikolis, A. et al. Chronic Wound Care Management and Research. A prospective case series evaluating the safety and efficacy of the Klox BioPhotonic System in venous leg ulcers (PDF)
2016 – Regeimbal, J. et al. Journal for Antimicrobial Agents and Chemotherapy. Personalized Therapeutic Cocktail of Wild Environmental Phages Rescues Mice from Acinetobacter baumannii Wound Infections (online)
2016 – Walters, J. et al. Eplasty. Healing Rates in a Multicenter Assessment of a Sterile, Room Temperature, Acellular Dermal Matrix Versus Conventional Care Wound Management and an Active Comparator in the Treatment of Full-Thickness Diabetic Foot Ulcers
2015 – Cazzell, M. et al. Advances in Wound Care (New Rochelle). The Management of Diabetic Foot Ulcers with Porcine Small Intestine Submucosa Tri-Layer Matrix: A Randomized Controlled Trial (online)
2015 – Chan, R. et al. Plastic and Reconstructive Surgery Autologous Graft Thickness Affects Scar Contraction and Quality in a Porcine Excisional Wound Model (online)
2015 – Foltynski, P. et al. PLoS One. Wound Area Measurement with Digital Planimetry: Improved Accuracy and Precision with Calibration Based on 2 Rulers (online)
2015 – Foubert, P. et al. Burns. Uncultured adipose-derived regenerative cells (ADRCs) seeded in collagen scaffold improves dermal regeneration, enhancing early vascularization and structural organization following thermal burns (PDF)
2015 – Motley, T. et al. Journal of Foot and Ankle Research. Cost-effectiveness of clostridial collagenase ointment on wound closure in patients with diabetic foot ulcers: economic analysis of results from a multicenter, randomized, open-label trial (online)
2015 – Romanelli, M. et al. Drug Design, Development and Therapy. Clinical evaluation of the efficacy and safety of a medical device in various forms containing Triticum vulgare for the treatment of venous leg ulcers – a randomized pilot study (online)
2015 – Thompson, G. et al. Antimicrobial Agents and Chemotherapy. Evaluation of Gallium Citrate Formulations against a Multidrug-Resistant Strain of Klebsiella pneumoniae in a Murine Wound Model of Infection (online)
2015 – Tuffour, J. et al. The American Journal of Tropical Medicine and Hygiene. Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study (online)
2015 – Van Hecke, L. et al. The Veterinary Journal. Comparison of a new laser beam wound camera and a digital photoplanimetry-based method for wound measurement in horses (online)
2014 – Armstrong, D. G. et al. Diabetic Medicine. Treatment effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial (online)
2014 – Thompson, M. G. et al. Antimicrobial Agents and Chemotherapy. Validation of a Novel Murine Wound Model of Acinetobacter baumannii Infection (online)
2014 – Zeller, T. et al. et al, Trials. IN.PACT Amphirion paclitaxel eluting balloon versus standard percutaneous transluminal angioplasty for infrapopliteal revascularization of critical limb ischemia: rationale and protocol for an ongoing randomized controlled trial. (online)
2013 – Bowling, F. L. et al. Journal of Diabetes Science and Technology. Applying 21st Century Imaging Technology to Wound Healing: An Avant-Gardist Approach (online)
2013 – Davis, K. E. et al. Journal of Diabetes Science and Technology. Validation of a Laser-Assisted Wound Measurement Device for Measuring Wound Volume (online)
2013 – Foltynski, P. et al. Diabetes Technology and Therapeutics. Accuracy and precision of selected wound area measurement methods in diabetic foot ulceration (online)
2013 – Lantis, J. C., Kirsner, R. S., Lee, T. D. et al. Journal of Vascular Surgery. The influence of patient and wound variables on healing of venous leg ulcers in a randomized controlled trial of growth-arrested allogeneic keratinocytes and fibroblasts (online)
2013 – Lev-Tov, H. et al. Trials. Cellular versus acellular matrix devices in treatment of diabetic foot ulcers: study protocol for a comparative efficacy randomized controlled trial (online)
2012 – Fletcher, J. Wounds UK. The use of electronic data capture devices in wound care settings (PDF)
2012 – Kirsner, R. S. et al. The Lancet. Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial (PDF)
2012 – Miller, C. et al. Advances in Skin and Wound Care. Interrater and Intrarater Reliability of Silhouette Wound Imaging Device (online)
2012 – Nixon, M. et al. Poster. Accuracy and repeatability of area measurements on large areas of erythema using an electronic wound measurement device (SilhouetteMobile) (PDF)
2012 – Nixon, M. et al. Poster. Assessment of accuracy and repeatablility on wound models of a new hand-held, electronic wound measurement device (SilhouetteStar) (PDF)
2011 – Hammond, C & Nixon, M. Journal of Wound Ostomy Continence Nursing. The reliability of a handheld wound measurement and documentation device in clinical practice (online)
2011 – Kieser, D & Hammond, C. Advanced Skin Wound Care. Leading wound care technology: The ARANZ medical silhouette (online)
2011 – Wikkerink, M. et al. WCS Nieuws. Wound initial size reduction as a predictor of full wound healing in patients with leg ulcers (Dutch) (PDF)
2010 – Rogers, L. et al. Journal of Diabetes Science Technology. Digital Planimetry Results in More Accurate Wound Measurements: A Comparison to Standard Ruler Measurements (online)
2009 – Khashram, M. et al. Journal of Wound Care. Effect of TNP on the microbiology of venous leg ulcers: a pilot study (online)
2009 – Nixon, D. et al. Journal of Wound Technology. Measurement of Diabetic Foot Ulcers using SilhouetteMobile (PDF)
2008 – Hammond, C. et al. Acute Care Perspectives. The ARANZ Medical Silhouette: An innovative wound measurement and documentation system (PDF)
2008 – Kapp, S. et al. Poster. Implementation of wound assessment data into a hand-held, PDA-based wound measurement and documentation device, and evaluation in clinical practice (PDF)
2008 – Romanelli, M. et al. Wounds. Clinical evaluation of a wound measurement and documentation system (online)

Articles

Silhouette provides the evidence to change practice for EB sufferers, Mo Blishen, EB Clinical Nurse, Debra NZ
What is a blinded clinical trial and can it give you better outcomes?
Improving patient experiences in a diabetic foot clinic, Rebecca Aburn, RN MN
Why are wound cameras now exempt from gaining FDA approvals? Maree Roan, Quality and Regulatory Manager, ARANZ Medical
Environmental Considerations for Infection Control during Wound Measurement, Maree Roan, Quality and Regulatory Manager, ARANZ Medical
Assessment of Accuracy and Repeatability on Wound models of a New Hand-held, Electronic Wound Measurement Device. Mark A Nixon, MBChB; Thomas R Rivett, BE; Brent S Robinson, PhD. ARANZ Medical
Manual measurement leads to pain for providers
WHO Buruli Ulcer clinical trial
Abstract: Silhouette – a novel 3D wound measurement system. T Jemmott, M Bates, J Lucas, V Vincent, ME Edmonds.Diabetic Foot Clinic, King’s College Hospital, London, UK. Presented to the Diabetic Foot Study Group, 2013
Clinical research: Will your endpoint evidence stand up to scrutiny?
New technology makes big difference to tracking wound healing, Canterbury District Health Board (CDHB)

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